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Distinct Protein Kinase A Anchoring Proteins Direct Prostaglandin E(2) Modulation of Toll-like Receptor Signaling in Alveolar Macrophages
Toll-like receptors (TLRs) direct a proinflammatory program in macrophages. One mediator whose generation is induced by TLR ligation is prostaglandin E(2) (PGE(2)), which is well known to increase intracellular cAMP upon G protein-coupled receptor ligation. How PGE(2)/cAMP shapes the nascent TLR res...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3058957/ https://ncbi.nlm.nih.gov/pubmed/21247892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.187815 |
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