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Prostaglandin E(2) Reduces Toll-Like Receptor 4 Expression in Alveolar Macrophages by Inhibition of Translation

Alveolar macrophages (AMs) represent the first line of innate immune defense in the lung. AMs use pattern recognition receptors (PRRs) to sense pathogens. The best studied PRR is Toll-like receptor (TLR)4, which detects LPS from gram-negative bacteria. The lipid mediator prostaglandin (PG)E(2) dampe...

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Detalhes bibliográficos
Main Authors: Degraaf, Angela Juliette, Zasłona, Zbigniew, Bourdonnay, Emilie, Peters-Golden, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148041/
https://ncbi.nlm.nih.gov/pubmed/24601788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0495OC
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