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Prostaglandin E(2) Reduces Toll-Like Receptor 4 Expression in Alveolar Macrophages by Inhibition of Translation
Alveolar macrophages (AMs) represent the first line of innate immune defense in the lung. AMs use pattern recognition receptors (PRRs) to sense pathogens. The best studied PRR is Toll-like receptor (TLR)4, which detects LPS from gram-negative bacteria. The lipid mediator prostaglandin (PG)E(2) dampe...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Thoracic Society
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4148041/ https://ncbi.nlm.nih.gov/pubmed/24601788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0495OC |
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