Prostaglandin E(2) restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling

Prostaglandin E(2) (PGE(2)) is a lipid mediator that acts by ligating 4 distinct G protein–coupled receptors, E prostanoid (EP) 1 to 4. Previous studies identified the importance of PGE(2) in regulating macrophage functions, but little is known about its effect on macrophage maturation. Macrophage m...

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Detalhes bibliográficos
Main Authors: Zasłona, Zbigniew, Serezani, Carlos H., Okunishi, Katsuhide, Aronoff, David M., Peters-Golden, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311259/
https://ncbi.nlm.nih.gov/pubmed/22234697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-08-374207
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