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Expression, purification and crystallization of adenosine 1408 aminoglycoside-resistance rRNA methyltransferases for structural studies

High-level resistance to a broad spectrum of aminoglycoside antibiotics can arise through either N7-methyl guanosine 1405 (m(7)G1405) or N1-methyl adenosine 1408 (m(1)A1408) modifications at the drug binding site in the bacterial 30S ribosomal subunit decoding center. Two distinct families of 16S ri...

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Bibliografiske detaljer
Main Authors: Zelinskaya, Natalia, Rankin, C. Robert, Macmaster, Rachel, Savic, Miloje, Conn, Graeme L.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966526/
https://ncbi.nlm.nih.gov/pubmed/20667473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pep.2010.07.005
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