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Expression, purification and crystallization of adenosine 1408 aminoglycoside-resistance rRNA methyltransferases for structural studies
High-level resistance to a broad spectrum of aminoglycoside antibiotics can arise through either N7-methyl guanosine 1405 (m(7)G1405) or N1-methyl adenosine 1408 (m(1)A1408) modifications at the drug binding site in the bacterial 30S ribosomal subunit decoding center. Two distinct families of 16S ri...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2966526/ https://ncbi.nlm.nih.gov/pubmed/20667473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pep.2010.07.005 |
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