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Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics

The 16S ribosomal RNA methyltransferase enzymes that modify nucleosides in the drug binding site to provide self-resistance in aminoglycoside-producing micro-organisms have been proposed to comprise two distinct groups of S-adenosyl-l-methionine (SAM)-dependent RNA enzymes, namely the Kgm and Kam fa...

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Bibliografiske detaljer
Main Authors: Savic, Miloje, Lovrić, Josip, Tomic, Tatjana Ilic, Vasiljevic, Branka, Conn, Graeme L.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760815/
https://ncbi.nlm.nih.gov/pubmed/19589804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp575
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