Structural insights into the function of aminoglycoside-resistance A1408 16S rRNA methyltransferases from antibiotic-producing and human pathogenic bacteria

X-ray crystal structures were determined of the broad-spectrum aminoglycoside-resistance A1408 16S rRNA methyltransferases KamB and NpmA, from the aminoglycoside-producer Streptoalloteichus tenebrarius and human pathogenic Escherichia coli, respectively. Consistent with their common function, both a...

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Bibliographic Details
Main Authors: Macmaster, Rachel, Zelinskaya, Natalia, Savic, Miloje, Rankin, C. Robert, Conn, Graeme L.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995053/
https://ncbi.nlm.nih.gov/pubmed/20639535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq627
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