Caricamento...

Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977

A phosphoramidate prodrug of 2′-deoxy-2′-α-fluoro-β-C-methyluridine-5′-monophosphate, PSI-7851, demonstrates potent anti-hepatitis C virus (HCV) activity both in vitro and in vivo. PSI-7851 is a mixture of two diastereoisomers, PSI-7976 and PSI-7977, with PSI-7977 being the more active inhibitor of...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Murakami, Eisuke, Tolstykh, Tatiana, Bao, Haiying, Niu, Congrong, Steuer, Holly M. Micolochick, Bao, Donghui, Chang, Wonsuk, Espiritu, Christine, Bansal, Shalini, Lam, Angela M., Otto, Michael J., Sofia, Michael J., Furman, Phillip A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966047/
https://ncbi.nlm.nih.gov/pubmed/20801890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.161802
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !