DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-Trans Isomerisation in Domain II of NS5A

DEB025/Debio 025 (Alisporivir) is a cyclophilin (Cyp)-binding molecule with potent anti-hepatitis C virus (HCV) activity both in vitro and in vivo. It is currently being evaluated in phase II clinical trials. DEB025 binds to CypA, a peptidyl-prolyl cis-trans isomerase which is a crucial cofactor for...

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Hlavní autoři: Coelmont, Lotte, Hanoulle, Xavier, Chatterji, Udayan, Berger, Carola, Snoeck, Joke, Bobardt, Michael, Lim, Precious, Vliegen, Inge, Paeshuyse, Jan, Vuagniaux, Grégoire, Vandamme, Anne-Mieke, Bartenschlager, Ralf, Gallay, Philippe, Lippens, Guy, Neyts, Johan
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965138/
https://ncbi.nlm.nih.gov/pubmed/21060866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013687
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