Alisporivir Inhibition of Hepatocyte Cyclophilins Reduces HBV Replication and Hepatitis B Surface Antigen Production

BACKGROUND & AIMS: Cyclophilins are host factors required for hepatitis C virus replication. Cyclophilin inhibitors such as alisporivir have shown strong anti–hepatitis C virus activity in vitro and in clinical studies. However, little is known about whether hepatocyte cyclophilins are involved...

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Detalhes bibliográficos
Publicado no:Gastroenterology
Main Authors: Phillips, Sandra, Chokshi, Shilpa, Chatterji, Udayan, Riva, Antonio, Bobardt, Michael, Williams, Roger, Gallay, Philippe, Naoumov, Nikolai V.
Formato: Artigo
Idioma:Inglês
Publicado em: AGA Institute. Published by Elsevier Inc. 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7172380/
https://ncbi.nlm.nih.gov/pubmed/25305505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.10.004
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