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The Isomerase Active Site of Cyclophilin A Is Critical for Hepatitis C Virus Replication
Cyclosporine A and nonimmunosuppressive cyclophilin (Cyp) inhibitors such as Debio 025, NIM811, and SCY-635 block hepatitis C virus (HCV) replication in vitro. This effect was recently confirmed in HCV-infected patients where Debio 025 treatment dramatically decreased HCV viral load, suggesting that...
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| Main Authors: | , , , , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
American Society for Biochemistry and Molecular Biology
2009
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2719337/ https://ncbi.nlm.nih.gov/pubmed/19380579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.007625 |
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