The Isomerase Active Site of Cyclophilin A Is Critical for Hepatitis C Virus Replication

Cyclosporine A and nonimmunosuppressive cyclophilin (Cyp) inhibitors such as Debio 025, NIM811, and SCY-635 block hepatitis C virus (HCV) replication in vitro. This effect was recently confirmed in HCV-infected patients where Debio 025 treatment dramatically decreased HCV viral load, suggesting that...

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Hlavní autoři: Chatterji, Udayan, Bobardt, Michael, Selvarajah, Suganya, Yang, Feng, Tang, Hengli, Sakamoto, Noayo, Vuagniaux, Gregoire, Parkinson, Tanya, Gallay, Philippe
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
RNA-Mediated Regulation and Noncoding RNAs
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719337/
https://ncbi.nlm.nih.gov/pubmed/19380579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.007625
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