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HCV RESISTANCE TO CYCLOSPORIN A DOES NOT CORRELATE WITH A RESISTANCE OF THE NS5A-CYCLOPHILIN A INTERACTION TO CYCLOPHILIN INHIBITORS
BACKGROUND & AIMS: The cyclophilin (Cyp) inhihibitors - cyclosporine A (CsA), NIM811, Debio 025 and SCY 635 - block HCV replication both in vitro and in vivo, and represent a novel class of potent anti-HCV agents. We and others showed that HCV relies on cyclophilin A (CypA) to replicate. We demo...
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Main Authors: | , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2884070/ https://ncbi.nlm.nih.gov/pubmed/20451281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2010.01.041 |
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