HCV RESISTANCE TO CYCLOSPORIN A DOES NOT CORRELATE WITH A RESISTANCE OF THE NS5A-CYCLOPHILIN A INTERACTION TO CYCLOPHILIN INHIBITORS

BACKGROUND & AIMS: The cyclophilin (Cyp) inhihibitors - cyclosporine A (CsA), NIM811, Debio 025 and SCY 635 - block HCV replication both in vitro and in vivo, and represent a novel class of potent anti-HCV agents. We and others showed that HCV relies on cyclophilin A (CypA) to replicate. We demo...

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Hauptverfasser: Chatterji, Udayan, Lim, Precious, Bobardt, Michael D., Wieland, Stefan, Cordek, Daniel G., Vuagniaux, Gregoire, Chisari, Francis, Cameron, Craig E., Targett-Adams, Paul, Parkinson, Tanya, Gallay, Philippe A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884070/
https://ncbi.nlm.nih.gov/pubmed/20451281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2010.01.041
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