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The Cyclophilin Inhibitor SCY-635 Disrupts Hepatitis C Virus NS5A-Cyclophilin A Complexes

The nonimmunosuppressive cyclophilin (Cyp) inhibitor SCY-635 blocks hepatitis C virus (HCV) replication both in vitro and in vivo and represents a novel potent anti-HCV agent. However, its mechanism of action remains to be fully elucidated. A growing body of evidence suggests that cyclophilin A (Cyp...

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Main Authors: Hopkins, Sam, Bobardt, Michael, Chatterji, Udayan, Garcia-Rivera, Jose A., Lim, Precious, Gallay, Philippe A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393457/
https://ncbi.nlm.nih.gov/pubmed/22585215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00693-12
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