trans-Complementation Rescue of Cyclophilin A-Deficient Viruses Reveals that the Requirement for Cyclophilin A in Human Immunodeficiency Virus Type 1 Replication Is Independent of Its Isomerase Activity

Human immunodeficiency virus type 1 (HIV-1) requires the incorporation of cyclophilin A (CypA) for replication. CypA is packaged by binding to the capsid (CA) region of Gag. This interaction is disrupted by cyclosporine (CsA). Preventing CypA incorporation, either by mutations in the binding region...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Saphire, Andrew C. S., Bobardt, Michael D., Gallay, Philippe A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Structure and Assembly
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135933/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11836403/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.76.5.2255-2262.2002
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