trans-Complementation Rescue of Cyclophilin A-Deficient Viruses Reveals that the Requirement for Cyclophilin A in Human Immunodeficiency Virus Type 1 Replication Is Independent of Its Isomerase Activity

Human immunodeficiency virus type 1 (HIV-1) requires the incorporation of cyclophilin A (CypA) for replication. CypA is packaged by binding to the capsid (CA) region of Gag. This interaction is disrupted by cyclosporine (CsA). Preventing CypA incorporation, either by mutations in the binding region...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Saphire, Andrew C. S., Bobardt, Michael D., Gallay, Philippe A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2002
Gaiak:
Structure and Assembly
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC135933/
https://ncbi.nlm.nih.gov/pubmed/11836403
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