trans-Complementation Rescue of Cyclophilin A-Deficient Viruses Reveals that the Requirement for Cyclophilin A in Human Immunodeficiency Virus Type 1 Replication Is Independent of Its Isomerase Activity

Human immunodeficiency virus type 1 (HIV-1) requires the incorporation of cyclophilin A (CypA) for replication. CypA is packaged by binding to the capsid (CA) region of Gag. This interaction is disrupted by cyclosporine (CsA). Preventing CypA incorporation, either by mutations in the binding region...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Saphire, Andrew C. S., Bobardt, Michael D., Gallay, Philippe A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2002
Ämnen:
Structure and Assembly
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC135933/
https://ncbi.nlm.nih.gov/pubmed/11836403
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk