trans-Complementation Rescue of Cyclophilin A-Deficient Viruses Reveals that the Requirement for Cyclophilin A in Human Immunodeficiency Virus Type 1 Replication Is Independent of Its Isomerase Activity

Human immunodeficiency virus type 1 (HIV-1) requires the incorporation of cyclophilin A (CypA) for replication. CypA is packaged by binding to the capsid (CA) region of Gag. This interaction is disrupted by cyclosporine (CsA). Preventing CypA incorporation, either by mutations in the binding region...

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Detalles Bibliográficos

Publicado en:	J Virol
Autores principales:	Saphire, Andrew C. S., Bobardt, Michael D., Gallay, Philippe A.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 2002
Materias:	Structure and Assembly
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135933/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11836403/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.76.5.2255-2262.2002
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