trans-Complementation Rescue of Cyclophilin A-Deficient Viruses Reveals that the Requirement for Cyclophilin A in Human Immunodeficiency Virus Type 1 Replication Is Independent of Its Isomerase Activity

Human immunodeficiency virus type 1 (HIV-1) requires the incorporation of cyclophilin A (CypA) for replication. CypA is packaged by binding to the capsid (CA) region of Gag. This interaction is disrupted by cyclosporine (CsA). Preventing CypA incorporation, either by mutations in the binding region...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Saphire, Andrew C. S., Bobardt, Michael D., Gallay, Philippe A.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Structure and Assembly
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135933/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11836403/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.76.5.2255-2262.2002
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