Debio 025, a Cyclophilin Binding Molecule, Is Highly Efficient in Clearing Hepatitis C Virus (HCV) Replicon-Containing Cells When Used Alone or in Combination with Specifically Targeted Antiviral Therapy for HCV (STAT-C) Inhibitors

Debio 025 is a potent inhibitor of hepatitis C virus (HCV) replication (J. Paeshuyse et al., Hepatology 43:761-770, 2006). In phase I clinical studies, monotherapy (a Debio 025 dose of 1,200 mg twice a day) resulted in a mean maximal decrease in the viral load of 3.6 log(10) units (R. Flisiak et al....

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Detalhes bibliográficos
Main Authors: Coelmont, Lotte, Kaptein, Suzanne, Paeshuyse, Jan, Vliegen, Inge, Dumont, Jean-Maurice, Vuagniaux, Grégoire, Neyts, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650540/
https://ncbi.nlm.nih.gov/pubmed/19104013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00939-08
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