Correlation of Naturally Occurring HIV-1 Resistance to DEB025 with Capsid Amino Acid Polymorphisms

DEB025 (alisporivir) is a synthetic cyclosporine with inhibitory activity against human immunodeficiency virus type-1 (HIV-1) and hepatitis C virus (HCV). It binds to cyclophilin A (CypA) and blocks essential functions of CypA in the viral replication cycles of both viruses. DEB025 inhibits clinical...

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Main Authors: Gallay, Philippe A., Ptak, Roger G., Bobardt, Michael D., Dumont, Jean-Maurice, Vuagniaux, Grégoire, Rosenwirth, Brigitte
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3705307/
https://ncbi.nlm.nih.gov/pubmed/23524389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v5030981
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