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The inhibitor of apoptosis proteins antagonist Debio 1143 promotes the PD-1 blockade-mediated HIV load reduction in blood and tissues of humanized mice

The immune checkpoint programmed cell death protein 1 (PD-1) plays a major role in T cell exhaustion in cancer and chronic HIV infection. The inhibitor of apoptosis protein antagonist Debio 1143 (D1143) enhances tumor cell death and synergizes with anti-PD-1 agents to promote tumor immunity and disp...

詳細記述

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書誌詳細
出版年:PLoS One
主要な著者: Bobardt, Michael, Kuo, Joseph, Chatterji, Udayan, Wiedemann, Norbert, Vuagniaux, Gregoire, Gallay, Philippe
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980394/
https://ncbi.nlm.nih.gov/pubmed/31978106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227715
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