Nuclear Imaging Study of the Pharmacodynamic Effects of Debio 1143, an Antagonist of Multiple Inhibitor of Apoptosis Proteins (IAPs), in a Triple-Negative Breast Cancer Model

BACKGROUND: Debio 1143, a potent orally available SMAC mimetic, targets inhibitors of apoptosis proteins (IAPs) members and is currently in clinical trials. In this study, nuclear imaging evaluated the effects of Debio 1143 on tumor cell death and metabolism in a triple-negative breast cancer (TNBC)...

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Detalhes bibliográficos
Publicado no:Contrast Media Mol Imaging
Main Authors: Bellaye, Pierre-Simon, Oudot, Alexandra, Vrigneaud, Jean-Marc, Raguin, Olivier, Bichat, Francis, Vaslin, Anne, Maby-El Hajjami, Hélène, Zanna, Claudio, Vuagniaux, Grégoire, Fumoleau, Pierre, Denat, Franck, Brunotte, François, Collin, Bertrand
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6305031/
https://ncbi.nlm.nih.gov/pubmed/30627061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/8494031
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