Assessing energetic contributions to binding from a disordered region in a protein-protein interaction

Many functional proteins are at least partially disordered prior to binding. Although the structural transitions upon binding of disordered protein regions can influence the affinity and specificity of protein complexes, their precise energetic contributions to binding are unknown. Here, we use a mo...

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Bibliografiske detaljer
Main Authors: Cho, Sangwoo, Swaminathan, Chittoor P., Bonsor, Daniel A., Kerzic, Melissa C., Guan, Rongjin, Yang, Jianying, Kieke, Michele C., Andersen, Peter S., Kranz, David M., Mariuzza, Roy A., Sundberg, Eric J.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964404/
https://ncbi.nlm.nih.gov/pubmed/20836565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1008968
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