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Structural Basis for Recognition of the T Cell Adaptor Protein SLP-76 by the SH3 Domain of Phospholipase Cγ1

The enzyme phospholipase Cγ1 (PLCγ1) is essential for Tcell signaling and activation. Following T cell receptor ligation, PLCγ1 interacts through its SH2 and SH3 domains with the adaptors LAT and SLP-76, respectively, to form a multiprotein signaling complex that leads to activation of PLCγ1 by Syk...

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Autores principales: Deng, Lu, Velikovsky, C. Alejandro, Swaminathan, Chittoor P., Cho, Sangwoo, Mariuzza, Roy A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2005
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753203/
https://ncbi.nlm.nih.gov/pubmed/16061254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2005.06.072
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