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Structural Basis for Recognition of the T Cell Adaptor Protein SLP-76 by the SH3 Domain of Phospholipase Cγ1
The enzyme phospholipase Cγ1 (PLCγ1) is essential for Tcell signaling and activation. Following T cell receptor ligation, PLCγ1 interacts through its SH2 and SH3 domains with the adaptors LAT and SLP-76, respectively, to form a multiprotein signaling complex that leads to activation of PLCγ1 by Syk...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2753203/ https://ncbi.nlm.nih.gov/pubmed/16061254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2005.06.072 |
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