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Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads

The transmembrane protein, linker for activation of T cells (LAT), is essential for T-cell activation and development. Phosphorylation of LAT at multiple tyrosines creates binding sites for the adaptors Gads and Grb2, leading to nucleation of multiprotein signaling complexes. Human LAT contains five...

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Main Authors: Cho, Sangwoo, Velikovsky, C Alejandro, Swaminathan, Chittoor P, Houtman, Jon C D, Samelson, Lawrence E, Mariuzza, Roy A
Format: Artigo
Jezik:Inglês
Izdano: 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC391073/
https://ncbi.nlm.nih.gov/pubmed/15029250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600168
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