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The Membrane Proximal Proline-Rich Region and Correct Order of C-Terminal Tyrosines on the Adaptor Protein LAT Are Required For TCR-Mediated Signaling and Downstream Functions

The primary activating receptor for T cells is the T cell receptor (TCR), which is stimulated upon binding to an antigen/MHC complex. TCR activation results in the induction of regulated signaling pathways vital for T cell differentiation, cellular adhesion and cytokine release. A critical TCR-induc...

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Bibliografiske detaljer
Udgivet i:Cell Signal
Main Authors: Tremblay, Mikaela M., Ollinger, Tomye, Houtman, Jon C.D.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7669716/
https://ncbi.nlm.nih.gov/pubmed/32979494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2020.109790
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