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The Membrane Proximal Proline-Rich Region and Correct Order of C-Terminal Tyrosines on the Adaptor Protein LAT Are Required For TCR-Mediated Signaling and Downstream Functions
The primary activating receptor for T cells is the T cell receptor (TCR), which is stimulated upon binding to an antigen/MHC complex. TCR activation results in the induction of regulated signaling pathways vital for T cell differentiation, cellular adhesion and cytokine release. A critical TCR-induc...
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| Publicado no: | Cell Signal |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7669716/ https://ncbi.nlm.nih.gov/pubmed/32979494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2020.109790 |
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