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Proline-rich tyrosine kinase 2 controls PI3-kinase activation downstream of the T cell antigen receptor in human T cells

TCR-induced signaling controls T cell activation that drives adaptive immunity against infections, but it can also induce dysfunctional T cell responses that promote pathologic disease. The PI3K pathway regulates many downstream effector responses after TCR stimulation. However, the molecular mechan...

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Podrobná bibliografie
Vydáno v:J Leukoc Biol
Hlavní autoři: Chapman, Nicole M., Yoder, Ashley N., Barbón, Kathryn M., Bilal, Mahmood Y., Connolly, Sean F., Houtman, Jon C. D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Leukocyte Biology 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304419/
https://ncbi.nlm.nih.gov/pubmed/25387834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.2A1013-568RRR
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