Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis

Accumulating evidence shows that RAGE has an important function in the pathogenesis of sepsis. However, the mechanisms by which RAGE transduces signals to downstream kinase cascades during septic shock are not clear. Here, we identify SLP76 as a binding partner for the cytosolic tail of RAGE both in...

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發表在:Nat Commun
Main Authors: Yan, Zhengzheng, Luo, Haihua, Xie, Bingyao, Tian, Tian, Li, Shan, Chen, Zhixia, Liu, Jinghua, Zhao, Xuwen, Zhang, Liyong, Deng, Yongqiang, Billiar, Timothy R., Jiang, Yong
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7804203/
https://ncbi.nlm.nih.gov/pubmed/33436632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20577-3
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