Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis

Accumulating evidence shows that RAGE has an important function in the pathogenesis of sepsis. However, the mechanisms by which RAGE transduces signals to downstream kinase cascades during septic shock are not clear. Here, we identify SLP76 as a binding partner for the cytosolic tail of RAGE both in...

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Publicat a:Nat Commun
Autors principals: Yan, Zhengzheng, Luo, Haihua, Xie, Bingyao, Tian, Tian, Li, Shan, Chen, Zhixia, Liu, Jinghua, Zhao, Xuwen, Zhang, Liyong, Deng, Yongqiang, Billiar, Timothy R., Jiang, Yong
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7804203/
https://ncbi.nlm.nih.gov/pubmed/33436632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20577-3
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