Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy

Unknown molecular responses to sarcomere protein gene mutations account for pathologic remodeling in hypertrophic cardiomyopathy (HCM), producing myocyte growth and increased cardiac fibrosis. To determine if hypertrophic signals activated myocyte enhancer factor-2 (Mef2), we studied mice carrying t...

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Hlavní autoři: Konno, Tetsuo, Chen, Dan, Wang, Libin, Wakimoto, Hiroko, Teekakirikul, Polakit, Nayor, Matthew, Kawana, Masataka, Eminaga, Seda, Gorham, Joshua M., Pandya, Kumar, Smithies, Oliver, Naya, Francisco J., Olson, Eric N., Seidman, J. G., Seidman, Christine E.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964244/
https://ncbi.nlm.nih.gov/pubmed/20923879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012826107
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