Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β

Mutations in sarcomere protein genes can cause hypertrophic cardiomyopathy (HCM), a disorder characterized by myocyte enlargement, fibrosis, and impaired ventricular relaxation. Here, we demonstrate that sarcomere protein gene mutations activate proliferative and profibrotic signals in non-myocyte c...

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Detalhes bibliográficos
Main Authors: Teekakirikul, Polakit, Eminaga, Seda, Toka, Okan, Alcalai, Ronny, Wang, Libin, Wakimoto, Hiroko, Nayor, Matthew, Konno, Tetsuo, Gorham, Joshua M., Wolf, Cordula M., Kim, Jae B., Schmitt, Joachim P., Molkentin, Jefferey D., Norris, Russell A., Tager, Andrew M., Hoffman, Stanley R., Markwald, Roger R., Seidman, Christine E., Seidman, Jonathan G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947222/
https://ncbi.nlm.nih.gov/pubmed/20811150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42028
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