Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β

Mutations in sarcomere protein genes can cause hypertrophic cardiomyopathy (HCM), a disorder characterized by myocyte enlargement, fibrosis, and impaired ventricular relaxation. Here, we demonstrate that sarcomere protein gene mutations activate proliferative and profibrotic signals in non-myocyte c...

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Main Authors: Teekakirikul, Polakit, Eminaga, Seda, Toka, Okan, Alcalai, Ronny, Wang, Libin, Wakimoto, Hiroko, Nayor, Matthew, Konno, Tetsuo, Gorham, Joshua M., Wolf, Cordula M., Kim, Jae B., Schmitt, Joachim P., Molkentin, Jefferey D., Norris, Russell A., Tager, Andrew M., Hoffman, Stanley R., Markwald, Roger R., Seidman, Christine E., Seidman, Jonathan G.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947222/
https://ncbi.nlm.nih.gov/pubmed/20811150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42028
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