Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy

Unknown molecular responses to sarcomere protein gene mutations account for pathologic remodeling in hypertrophic cardiomyopathy (HCM), producing myocyte growth and increased cardiac fibrosis. To determine if hypertrophic signals activated myocyte enhancer factor-2 (Mef2), we studied mice carrying t...

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Autors principals: Konno, Tetsuo, Chen, Dan, Wang, Libin, Wakimoto, Hiroko, Teekakirikul, Polakit, Nayor, Matthew, Kawana, Masataka, Eminaga, Seda, Gorham, Joshua M., Pandya, Kumar, Smithies, Oliver, Naya, Francisco J., Olson, Eric N., Seidman, J. G., Seidman, Christine E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964244/
https://ncbi.nlm.nih.gov/pubmed/20923879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012826107
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