Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy

Unknown molecular responses to sarcomere protein gene mutations account for pathologic remodeling in hypertrophic cardiomyopathy (HCM), producing myocyte growth and increased cardiac fibrosis. To determine if hypertrophic signals activated myocyte enhancer factor-2 (Mef2), we studied mice carrying t...

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Autori principali: Konno, Tetsuo, Chen, Dan, Wang, Libin, Wakimoto, Hiroko, Teekakirikul, Polakit, Nayor, Matthew, Kawana, Masataka, Eminaga, Seda, Gorham, Joshua M., Pandya, Kumar, Smithies, Oliver, Naya, Francisco J., Olson, Eric N., Seidman, J. G., Seidman, Christine E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964244/
https://ncbi.nlm.nih.gov/pubmed/20923879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012826107
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