Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy

Unknown molecular responses to sarcomere protein gene mutations account for pathologic remodeling in hypertrophic cardiomyopathy (HCM), producing myocyte growth and increased cardiac fibrosis. To determine if hypertrophic signals activated myocyte enhancer factor-2 (Mef2), we studied mice carrying t...

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Bibliografiske detaljer
Main Authors: Konno, Tetsuo, Chen, Dan, Wang, Libin, Wakimoto, Hiroko, Teekakirikul, Polakit, Nayor, Matthew, Kawana, Masataka, Eminaga, Seda, Gorham, Joshua M., Pandya, Kumar, Smithies, Oliver, Naya, Francisco J., Olson, Eric N., Seidman, J. G., Seidman, Christine E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964244/
https://ncbi.nlm.nih.gov/pubmed/20923879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012826107
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