Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1

Aggregation of α-synuclein (αS) is involved in the pathogenesis of Parkinson's disease (PD) and a variety of related neurodegenerative disorders. The physiological function of αS is largely unknown. We demonstrate with in vitro vesicle fusion experiments that αS has an inhibitory function on me...

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Main Authors: Kamp, Frits, Exner, Nicole, Lutz, Anne Kathrin, Wender, Nora, Hegermann, Jan, Brunner, Bettina, Nuscher, Brigitte, Bartels, Tim, Giese, Armin, Beyer, Klaus, Eimer, Stefan, Winklhofer, Konstanze F, Haass, Christian
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964170/
https://ncbi.nlm.nih.gov/pubmed/20842103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.223
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