Loss of Parkin or PINK1 Function Increases Drp1-dependent Mitochondrial Fragmentation

Loss-of-function mutations in the parkin gene (PARK2) and PINK1 gene (PARK6) are associated with autosomal recessive parkinsonism. PINK1 deficiency was recently linked to mitochondrial pathology in human cells and Drosophila melanogaster, which can be rescued by parkin, suggesting that both genes pl...

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Autors principals: Lutz, A. Kathrin, Exner, Nicole, Fett, Mareike E., Schlehe, Julia S., Kloos, Karina, Lämmermann, Kerstin, Brunner, Bettina, Kurz-Drexler, Annerose, Vogel, Frank, Reichert, Andreas S., Bouman, Lena, Vogt-Weisenhorn, Daniela, Wurst, Wolfgang, Tatzelt, Jörg, Haass, Christian, Winklhofer, Konstanze F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Molecular Basis of Cell and Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755701/
https://ncbi.nlm.nih.gov/pubmed/19546216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.035774
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