Parkin Mediates Neuroprotection through Activation of IκB Kinase/Nuclear Factor-κB Signaling

Mutations in the parkin gene are a major cause of autosomal recessive Parkinson's disease. Here we show that the E3 ubiquitin ligase parkin activates signaling through the IκB kinase (IKK)/nuclear factor κB (NF-κB) pathway. Our analysis revealed that activation of this signaling cascade is caus...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Henn, Iris H., Bouman, Lena, Schlehe, Julia S., Schlierf, Anita, Schramm, Julia E., Wegener, Elmar, Nakaso, Kazuhiro, Culmsee, Carsten, Berninger, Benedikt, Krappmann, Daniel, Tatzelt, Jörg, Winklhofer, Konstanze F.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673568/
https://ncbi.nlm.nih.gov/pubmed/17314283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5537-06.2007
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