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Parkin Mediates Neuroprotection through Activation of IκB Kinase/Nuclear Factor-κB Signaling
Mutations in the parkin gene are a major cause of autosomal recessive Parkinson's disease. Here we show that the E3 ubiquitin ligase parkin activates signaling through the IκB kinase (IKK)/nuclear factor κB (NF-κB) pathway. Our analysis revealed that activation of this signaling cascade is caus...
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| Publicado no: | J Neurosci |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6673568/ https://ncbi.nlm.nih.gov/pubmed/17314283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5537-06.2007 |
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