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Degradation of Bcl10 Induced by T-Cell Activation Negatively Regulates NF-κB Signaling
Bcl10 is a critical regulator of NF-κB activity in T and B cells, coupling antigen receptor signaling to NF-κB activation via protein kinase C (PKC). Here we show that PKC or T-cell receptor (TCR)/CD28 signaling results in downregulation of Bcl10 protein levels, thereby attenuating NF-κB transcripti...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC387748/ https://ncbi.nlm.nih.gov/pubmed/15082780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.9.3860-3873.2004 |
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