Degradation of Bcl10 Induced by T-Cell Activation Negatively Regulates NF-κB Signaling

Bcl10 is a critical regulator of NF-κB activity in T and B cells, coupling antigen receptor signaling to NF-κB activation via protein kinase C (PKC). Here we show that PKC or T-cell receptor (TCR)/CD28 signaling results in downregulation of Bcl10 protein levels, thereby attenuating NF-κB transcripti...

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Detalhes bibliográficos
Main Authors: Scharschmidt, Erika, Wegener, Elmar, Heissmeyer, Vigo, Rao, Anjana, Krappmann, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC387748/
https://ncbi.nlm.nih.gov/pubmed/15082780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.9.3860-3873.2004
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