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The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

The etiologies of neurodegenerative diseases may be diverse; however, a common pathological denominator is the formation of aberrant protein conformers and the occurrence of pathognomonic proteinaceous deposits. Different approaches coming from neuropathology, genetics, animal modeling and biophysic...

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Bibliografische gegevens
Hoofdauteurs: Winklhofer, Konstanze F, Tatzelt, Jörg, Haass, Christian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2008
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234348/
https://ncbi.nlm.nih.gov/pubmed/18216876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601930
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