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Separating DNA with different topologies by atomic force microscopy in comparison with gel electrophoresis

Atomic force microscopy, which is normally used for DNA imaging to gain qualitative results, can also be used for quantitative DNA research, at a single-molecular level. Here, we evaluate the performance of AFM imaging specifically for quantifying supercoiled and relaxed plasmid DNA fractions within...

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Detalhes bibliográficos
Main Authors: Jiang, Yong, Rabbi, Mahir, Mieczkowski, Piotr A., Marszalek, Piotr E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963572/
https://ncbi.nlm.nih.gov/pubmed/20799746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp105603k
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