Detecting Ultraviolet Damage in Single DNA Molecules by Atomic Force Microscopy

We report detection and quantification of ultraviolet (UV) damage in DNA at a single molecule level by atomic force microscopy (AFM). By combining the supercoiled plasmid relaxation assay with AFM imaging, we find that high doses of medium wave ultraviolet (UVB) and short wave ultraviolet (UVC) ligh...

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Bibliographic Details
Main Authors: Jiang, Yong, Ke, Changhong, Mieczkowski, Piotr A., Marszalek, Piotr E.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2007
Subjects:
Spectroscopy, Imaging, Other Techniques
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948057/
https://ncbi.nlm.nih.gov/pubmed/17483180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.108209
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