The Force-Driven Conformations of Heparin Studied with Single Molecule Force Microscopy

Using single molecule force spectroscopy we examine the response of heparin chains to mechanical stretching. We find that at forces below 200 pN heparin behaves as a simple entropic spring. At ∼200 pN heparin displays a large enthalpic elasticity, which is evident as a pronounced plateau in the forc...

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Bibliographic Details
Main Authors: Marszalek, Piotr E., Oberhauser, Andres F., Li, Hongbin, Fernandez, Julio M.
Format: Artigo
Language:Inglês
Published: Biophysical Society 2003
Subjects:
Spectroscopy, Imaging, Other Techniques
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303493/
https://ncbi.nlm.nih.gov/pubmed/14507732
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