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A species-generalized probabilistic model-based definition of CpG islands

The DNA of most vertebrates is depleted in CpG dinucleotides, the target for DNA methylation. The remaining CpGs tend to cluster in regions referred to as CpG islands (CGI). CGI have been useful as marking functionally relevant epigenetic loci for genome studies. For example, CGI are enriched in the...

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Main Authors: Irizarry, Rafael A., Wu, Hao, Feinberg, Andrew P.
格式: Artigo
語言:Inglês
出版: 2009
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962567/
https://ncbi.nlm.nih.gov/pubmed/19777308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00335-009-9222-5
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