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Redefining CpG islands using hidden Markov models

The DNA of most vertebrates is depleted in CpG dinucleotide: a C followed by a G in the 5′ to 3′ direction. CpGs are the target for DNA methylation, a chemical modification of cytosine (C) heritable during cell division and the most well-characterized epigenetic mechanism. The remaining CpGs tend to...

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Détails bibliographiques
Auteurs principaux: Wu, Hao, Caffo, Brian, Jaffee, Harris A., Irizarry, Rafael A., Feinberg, Andrew P.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883304/
https://ncbi.nlm.nih.gov/pubmed/20212320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxq005
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