Molecular Mechanism of Terbinafine Resistance in Saccharomyces cerevisiae

Ten mutants of the yeast Saccharomyces cerevisiae resistant to the antimycotic terbinafine were isolated after chemical or UV mutagenesis. Molecular analysis of these mutants revealed single base pair exchanges in the ERG1 gene coding for squalene epoxidase, the target of terbinafine. The mutants di...

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Detalhes bibliográficos
Main Authors: Leber, Regina, Fuchsbichler, Sandra, Klobučníková, Vlasta, Schweighofer, Natascha, Pitters, Eva, Wohlfarter, Kathrin, Lederer, Mojca, Landl, Karina, Ruckenstuhl, Christoph, Hapala, Ivan, Turnowsky, Friederike
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC296195/
https://ncbi.nlm.nih.gov/pubmed/14638499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.12.3890-3900.2003
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