Molecular Mechanism of Terbinafine Resistance in Saccharomyces cerevisiae

Ten mutants of the yeast Saccharomyces cerevisiae resistant to the antimycotic terbinafine were isolated after chemical or UV mutagenesis. Molecular analysis of these mutants revealed single base pair exchanges in the ERG1 gene coding for squalene epoxidase, the target of terbinafine. The mutants di...

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Autors principals: Leber, Regina, Fuchsbichler, Sandra, Klobučníková, Vlasta, Schweighofer, Natascha, Pitters, Eva, Wohlfarter, Kathrin, Lederer, Mojca, Landl, Karina, Ruckenstuhl, Christoph, Hapala, Ivan, Turnowsky, Friederike
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC296195/
https://ncbi.nlm.nih.gov/pubmed/14638499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.12.3890-3900.2003
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