Molecular Mechanism of Terbinafine Resistance in Saccharomyces cerevisiae

Ten mutants of the yeast Saccharomyces cerevisiae resistant to the antimycotic terbinafine were isolated after chemical or UV mutagenesis. Molecular analysis of these mutants revealed single base pair exchanges in the ERG1 gene coding for squalene epoxidase, the target of terbinafine. The mutants di...

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Päätekijät: Leber, Regina, Fuchsbichler, Sandra, Klobučníková, Vlasta, Schweighofer, Natascha, Pitters, Eva, Wohlfarter, Kathrin, Lederer, Mojca, Landl, Karina, Ruckenstuhl, Christoph, Hapala, Ivan, Turnowsky, Friederike
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2003
Aiheet:
Mechanisms of Resistance
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC296195/
https://ncbi.nlm.nih.gov/pubmed/14638499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.12.3890-3900.2003
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