Molecular Mechanism of Terbinafine Resistance in Saccharomyces cerevisiae

Ten mutants of the yeast Saccharomyces cerevisiae resistant to the antimycotic terbinafine were isolated after chemical or UV mutagenesis. Molecular analysis of these mutants revealed single base pair exchanges in the ERG1 gene coding for squalene epoxidase, the target of terbinafine. The mutants di...

Full description

Saved in:
Bibliographic Details
Main Authors: Leber, Regina, Fuchsbichler, Sandra, Klobučníková, Vlasta, Schweighofer, Natascha, Pitters, Eva, Wohlfarter, Kathrin, Lederer, Mojca, Landl, Karina, Ruckenstuhl, Christoph, Hapala, Ivan, Turnowsky, Friederike
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC296195/
https://ncbi.nlm.nih.gov/pubmed/14638499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.12.3890-3900.2003
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items