Structure-Function Correlations of Two Highly Conserved Motifs in Saccharomyces cerevisiae Squalene Epoxidase

Saccharomyces cerevisiae squalene epoxidase contains two highly conserved motifs, 1 and 2, of unknown function. Amino acid substitutions in both regions reduce enzyme activity and/or alter allylamine sensitivity. In the homology model, these motifs flank the flavin adenine dinucleotide cofactor and...

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Hlavní autoři: Ruckenstuhl, Christoph, Poschenel, Andrea, Possert, Reinhard, Baral, Pravas Kumar, Gruber, Karl, Turnowsky, Friederike
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292544/
https://ncbi.nlm.nih.gov/pubmed/18212112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01282-07
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