Amino Acid Substitution in Trichophyton rubrum Squalene Epoxidase Associated with Resistance to Terbinafine

There has only been one clinically confirmed case of terbinafine resistance in dermatophytes, where six sequential Trichophyton rubrum isolates from the same patient were found to be resistant to terbinafine and cross-resistant to other squalene epoxidase (SE) inhibitors. Microsomal SE activity from...

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Hlavní autoři: Osborne, Colin S., Leitner, Ingrid, Favre, Bertrand, Ryder, Neil S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2005
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168638/
https://ncbi.nlm.nih.gov/pubmed/15980358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.7.2840-2844.2005
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